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Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks

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Reproduced from Kaneto et al (2021), an open source publication ( Indications: a FIRST LINE drug in the treatment of type II diabetes ( except when contraindicated - see below) Metformin has been in use for over 50 yrs, and remains the most commonly prescribed oral hypoglycemic (DeFronzo & Goodman, 1995

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